AqT®-Drug Assets for ADC Evaluation

Examples of AqT-Drugs
Mechanism of Action
Linkage
AqT®-MMAE Tubulin Inhibitor Releasable VC-PAB
AqT®-MMAF Releasable VC-PAB
AqT®-DM1 Protease-cleavable Linker
AqT®-Tubulysin A Protease-cleavable Linker
AqT®-Cryptophycin Analog 1 Protease-cleavable Linker
AqT®-Exatecan Topoisomerase Inhibitor (TopI and TopII) Protease-cleavable Linker
AqT®-SN38 Releasable Ester Bond
AqT®-Doxorubicin DNA Binding, Intercalatioin, or Alkylation Releasable Oxime Bond
AqT®-Duocarmycin Protease-cleavable Linker
AqT®-PBD Dimer Protease-cleavable Linker
AqT®-Calicheamicin Undisclosed
Undisclosed Sting Agnoist Protease-cleavable Linker
Undisclosed  Bcl2 Inhibitor Protease-cleavable Linker
AqT®-UM171 Human Hematopoietic Stem Cell Self-renewal Agonist Releasable VC-PAB
Undisclosed TLR7/8 Protease-cleavable Linker
(Note: Please inquire if your desired AqT-drugs is not listed.)